Mutational Analysis of Driver and Non-driver Mutations of Philadelphia Chromosome-negative Myeloproliferative Neoplasms; Diagnosis and Recent Advances in Treatment

World Journal of Cancer and Oncology Research | Vol 3, Issue 1

Figure 3

Structural domains of <i>MPL </i>showing Exon 10. EC, TM, and CD represent the extracellular, transmembrane, and cytoplasmic domains. The amino acid positions indicated represent the reported Exon 10 mutation hot spots;<i> </i>W515L or W515K in blue.

Figure 3. Structural domains of MPL showing Exon 10. EC, TM, and CD represent the extracellular, transmembrane, and cytoplasmic domains. The amino acid positions indicated represent the reported Exon 10 mutation hot spots; W515L or W515K in blue.