Mutational Analysis of Driver and Non-driver Mutations of Philadelphia Chromosome-negative Myeloproliferative Neoplasms; Diagnosis and Recent Advances in Treatment

World Journal of Cancer and Oncology Research | Vol 3, Issue 1

Figure 5

Acquired mutations associated with MPN pathogenesis showing constitutive activation of JAK/STAT, MAPK, and PI3K/Akt pathways; driver mutations (<i>JAK2</i>, <i>CALR</i> and <i>MPL</i>) in red; other mutations in yellow.

Figure 5. Acquired mutations associated with MPN pathogenesis showing constitutive activation of JAK/STAT, MAPK, and PI3K/Akt pathways; driver mutations (JAK2, CALR and MPL) in red; other mutations in yellow.