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5-Fluorouracil Ameliorates the Hematotoxicity Induced by Cyclophosphamide in Male Albino Rats
Universal Journal of Pharmacy and Pharmacology
| Vol 1, Issue 1
Table 1. WBCs, RBCs, and platelets count, Hb,and Hct of rat treated with cyclophosphamideand/or 5-fluorouracil.
| Groups Parameters | Control | CPA | 5-FU | CPA – 5-FU |
| Mean±E | Mean±E | Mean±E | Mean±E | |
| WBCs count (x103/µ) | 13.64±.65 bcd | 5.10±.50 acd | 10.0±.54 abd | 3.36±.63 abc |
| RBCs count (x106/µ) | 7.57±.22 bcd | 4.78±.16 acd | 5.72±.38 ab | 5.52±.47 ab |
| Hemoglobin concentration (g/dl) | 14.42±.66 bcd | 8.94±.40 acd | 12.04±.63 abd | 11.54±.53 abc |
| Hematocrit (%) | 44.12±.15 bcd | 24.96±.86 acd | 34.38±.77 ab | 33.66±.85 ab |
| Platelets count (103/μl) | 910.8±4.7 bc | 149.2±9.1 acd | 637.6±5.7 abd | 876.4±1.6 bc |
Significance at P < 0.05. CPA: cyclophosphamide; 5-FU: Fluorouracil, a Comparison of control and other groups; b Comparison of CPA and other groups; c Comparison of 5-FU and other groups; d Comparison of CPA - 5-FU and other groups.