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Quantifying 64 drugs, illicit substances, and D- and L- isomers in human oral fluid with liquid-liquid extraction
Open Journal of Medical Sciences
| Vol 3, Issue 1
Table 10. LC-MS/MS conditions for the three assays on a single oral fluid sample.
| P63 |
| THC |
| D- and L- | ||||
| Scan type | MRM |
| MRM |
| MRM | |||
| Ion source | Turbo spray | Turbo spray | Turbo spray | |||||
| Probe position | X = 5.15, Y = 5.4 | X = 5.15, Y = 6.40 | X=5.00, Y=5.2 | |||||
| Polarity: | Positive | Negative | Positive | |||||
| Run duration | 8 min | 1.5 min | 11 min | |||||
| Settling time (msec) | 5 | 0 | 0 | |||||
| Pause time (msec) | 5 | 5.0007 msec | 7.007 msec | |||||
| Curtain gas | 35 | 20 | 35 | |||||
| CAD gas | 8 | 4 | 4 | |||||
| ISV (V) | 5000 | -4000 | 5000 | |||||
| Temperature (°C) | 500 | 400 | 500 | |||||
| Ion Source Gas 1 (GS1) | 50 | 50 | 50 | |||||
| Ion Source Gas 2 (GS2) | 50 | 60 | 50 | |||||
| Q1/Q3 resolution | unit/unit | unit/unit | unit/unit | |||||
| CEM (V) |
| 2600 |
| 2400 |
| 2600 | ||
Note: multiple reaction monitoring (MRM); collision gas (CAD); ion source voltage (ISV); channel electron multiplier (CEM)