Articles

We have reported novel solid-cancer treatment modality of nano-thermal ablation therapy using two medical devices of 100kHz electromagnetic field radiator and heat-generating nanoparticles of MCL particle [1]. External 100kHz electromagnetic field radiation induced heat generation of MCL particle in tumor tissue and caused tumor specific cytotoxicity and blood vessel disruption [1]. MCL particle was designed to be about 100nm diameter and to move within tumor tissue by composing heat-generating magnetite (Fe<SUB>3</SUB>O<SUB>4</SUB>) with neutral and cationic lipids [1]. However, concerning 100kHz radiator, rational concept of its performance and specification was not fully discussed. Purpose of this seminar is to describe significance of 100kHz magnetic flux density for rational designing, specification and usage of the radiator, referring to our unpublished data during 2004~2025. At first, our calibration method of 100kHz magnetic flux density was shown, and then its application to density distribution analysis of our radiators HTS-5010H and Hi-Heater 5010 was described. And, based on density distribution profile of Hi-Heater 5010 radiator, effective density at tumor locus in the standard treatment condition of the therapy was confirmed 15mT. Based on the recorded data of clinical research using HTS-5010H radiator, safety radiation condition toward groin, breast, thigh, neck, chest and arm were shown with density distribution in patient bodies. With all respect, quoting MFH<SUP>®</SUP>300F (100kHz) radiator [2], availability of three types radiators for various target cancers was discussed on the basis of effective tumor density and mitigation of normal tissue heating. According to Design Control Guidance of medical device [3], design process of the radiator was exemplified by drafted documents of design input and output.

<b>Introduction:</b> Severe pre-eclampsia is a multisystem disorder associated with various ocular complications, however postpartum bilateral serous retinal detachment is uncommon and may threaten vision if not early recognized, thus requiring prompt management in order to prevent permanent visual loss. <b>Clinical Description:</b> A case of a 31-year-old woman, G3P0 with an in vitro fertilization and previous miscarriages, developed severe pre-eclampsia at 34 weeks of gestation. She underwent an emergency cesarean section for maternal indication. On the second postoperative day, she develops sudden unilateral blindness and blurred vision in the contralateral eye. Ophthalmological examination showed normal optics discs while MRI revealed bilateral serous retinal detachment. She was managed conservatively with strict blood pressure control, magnesium sulphate therapy and anticoagulation with full recovery of vision over 3 weeks without need of surgical intervention. <b>Discussion:</b> Postpartum retinal detachment is uncommon, most often serous and reversible. This case highlights that conservative management focusing on strict blood pressure control and supportive care was sufficient to avoid surgical intervention. Timely diagnosis and coordinated multidisciplinary management ensured complete visual recovery. <b>Conclusion:</b> Bilateral serous retinal detachment is a rare but reversible postpartum complication of severe pre-eclampsia. With early recognition, close monitoring and conservative management can lead to complete restoration of vision.

<b>Purpose:</b> Although the effect of loss of a loved one on depression is well established, very limited knowledge exists on racial differences in this effect. <b>Aim: </b>In the current study we compared Non-Hispanic White (NHW) and Non-Hispanic Black (NHB) Californians for the effects of loss of a loved one on depression in a representative sample of adults in California. <b>Methods:</b> This cross-sectional study used data from the Survey of California Adults on Serious Illness and End-of-Life 2019. Overall, 1603 people entered our study. We compared 901 (56.2%) NHB and 702 (43.8%) NHW adults (age 18 and older). Race/ethnicity, demographics (age and gender), socio-economic factors (education, income, employment, and marital status), religiosity, and health (self-rated health and number of chronic medical conditions), and depression were measured. To perform data analysis, we used logistic regression models. <b>Results:</b> In the pooled sample, loss of a loved one was not associated with self-reported depression, net of all covariates. Race, however, interacted with loss of a loved one on depression, suggesting a larger association for NHBs compared to NHWs. In race-specific models, loss of a loved one predicted depression for NHBs (<i>OR</i> = 1.54) but not NHWs (<i>OR</i> = 0.99). <b>Conclusion:</b> There are differences between NHBs and NHWs in the effect of loss of a loved one on depression. NHBs show a stronger association between loss of a loved one and depression than NHWs. This result is not in line with the NHB mental health paradox or with NHB resilience but is consistent with the notion that social relations may be more salient for NHBs than for NHWs.

A man in his 60s with multiple vascular comorbidities presented with sudden, painless vision loss in one eye. Although he had a high risk for atherosclerotic events, initial evaluation for stroke was negative for acute ischemia, but found to have markedly elevated inflammatory markers. Accordingly, giant cell arteritis was investigated and Ophthalmologic findings and fulfillment of the 2022 American College of Rheumatology/European Alliance of Associations for Rheumatology classification criteria supported the diagnosis of giant cell arteritis, despite a negative temporal artery biopsy. Management included high-dose glucocorticoids and delayed tocilizumab initiation due to the need for multiple vascular surgeries. Vision loss was irreversible, but systemic symptoms resolved and vascular interventions were successful. This case highlights the diagnostic and management complexities of biopsy-negative giant cell arteritis in patients with severe atherosclerotic vascular disease, emphasizing the importance of clinical judgment and established classification criteria when imaging and biopsy results are inconclusive.

This research explores the complex relationship between user-perceived Quality of Experience (QoE) and underlying network performance for multimedia traffic. As video streaming, online gaming, and interactive media dominate modern networks, ensuring consistent QoE has become a key challenge. The study develops a network performance model that integrates objective Quality of Service (QoS) parameters—such as delay, jitter, packet loss, and throughput—with subjective QoE metrics like Mean Opinion Score (MOS) and perceptual quality indices. Using simulation-based and analytical approaches, the paper evaluates how network conditions affect multimedia traffic behavior and user satisfaction. The results highlight critical thresholds for QoE degradation, enabling predictive modeling for adaptive multimedia delivery and real-time optimization. This work contributes to designing intelligent, user-centered network management systems capable of balancing resource efficiency and end-user satisfaction.